Sharanya S 
AUSTIN LAM 
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My Articles
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BDNF and Inflammation in Depression | PT. 4 & Bibliography
BY AUSTIN LAM BDNF: In charge of modulation and mediation of neuroinflammation BDNF expression can be said to have a bi-directional effect on neuroinflammation. By activating its receptor TrkB, its anti-inflammatory effects allow for neuroinflammatory modulation and neuroprotection. An in vitro study found that microglia acutely increased secretion of extracellular BDNF in the context of […]
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BDNF and Inflammation in Depression | PT. 3
BY AUSTIN LAM Inflammation in Depression‘The complex of melancholia behaves like an open wound’ – Sigmund Freud[69]‘Sickness behavior’ is a term which reflects immune activation and is often associated with depression. However, the criteria required for depression diagnosis often coincides with sickness behavior symptomology due to systemic inflammation ranging from lethargy, decreased appetite, reduced social […]
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BDNF and Inflammation in Depression | PT. 2
BY AUSTIN LAM BDNF in Depression Lowered BDNF levels have been associated with an increased frequency of depressive symptoms, summarising the neurotrophic hypothesis. Postmortem studies exhibit lowered levels of BDNF coupled with its receptor TrkB[31], with emphasis of reduced BDNF mRNA in regions such as the hippocampus[32] and amygdala[33]. Moreover, those who died of complete […]
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BDNF and Inflammation in Depression | PT. 1
BY AUSTIN LAM Depression as a mental disorder is amongst the most prominent causes of disability, suffered by an estimated 5% of adults, present in approximately 280 million people[1] . Major depressive disorder itself has caused the United States to suffer a societal economic burden totalling at around 333.7 billion dollars extending beyond the primary […]
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